Sensory and Neuroendocrine Physiology - T. Leinders-Zufall
Our research is directed towards a better understanding of the molecular and cellular events that mediate mammalian chemical communication, specifically those events underlying complex social behaviors such as aggression, maternal care, and mating. The overall goal is to integrate investigations aimed at understanding molecular membrane mechanisms underlying the recognition of specific signaling molecules in the olfactory system – such as odors, pathogens and hormones – with endocrine and immune function.
Research Focus:
- Mechanisms of odor and pathogen sensing in the olfactory system
- Neural pathways mediating olfactory-encoded innate social behaviors
- TRP channel function in neurons of the CNS and respiratory epithelium
Link contains all relevant questions regarding rules of conduct, statistical help, links to documenting (record keeping) and producing a thesis, etc.
dasGehirn.info: German portal of the NWG (Neurowissenschaftliche Gesellschaft), informing the public about the brain and its functions.
Movie about neuroscience at the CIPMM: Link
Special thanks to the various funding agencies for their support in the past and future !
Selected publications:
(OMIM search: link; PubMed search: link; NCIB nucleotide: link; ORCID: link)
Ojha NK, Zufall F, Leinders-Zufall (2023) Optical activation of photoswitchable TRPC ligands in the mammalian olfactory system using laser scanning confocal microscopy. In: Methods in Molecular Biology: The Olfactory System, Eds. Goldstein B and Matsunami H. link.
Perniss A, Boonen B, Tonach S, Thiel M, Poharkar K, Anouri WM, Keshavarz M, Papadakis T, Wiegand S, Pfeil U, Richter K, Althaus M, Oberwinkler J, Schütz B, Boehm U, Offermanns S, Leinders-Zufall T, Zufall F, Kummer W (2023) A succinate/SUCNR1-brush cell defense program in the tracheal epithelium. Science Advances
Koike K, Yoo SJ, Bleymehl K, Omura M, Zapiec B, Pyrski M, Blum T, Khan m, Bai Z, Leinders-Zufall T, Mombaerts P, Zufall F (2021) Danger perception and stress response through an olfactory sensor for the bacterial metabolite hydrogen sulfide. Neuron 109, 2469-2484.
Blum T, Moreno-Pérez A, Pyrski M, Bufe B, Arifovic A, Weissgerber P, Freichel M, Zufall F, Leinders-Zufall T (2019) Trpc5 deficieny causes hypoprolactinemia and altered function of oscillatory dopamine neurons in the arcuate nucleus. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5135-5143