Töle JC, Behrens M, Meyerhof W (2019) Taste receptor function. Handb Clin Neurol 164, 173-185.
Behrens M, Meyerhof W (2019) A role for taste receptors in (neuro)endocrinology. J. Neuroendocrinol 31, e12691.
Behrens M, Redel U, Blank K, Meyerhof W (2019) the human bitter taste receptor TAS2R7 facilitates the detection of bitter salts. Biochem Biophys Res Commun 512, 877-881.
Bitarafan V, Fitzgerald PCE, Little TJ, Meyerhof W, Wu T, Horowitz M, Feinle-Bisset C (2019) Effects of intraduodenal Infusion of the bitter tastant, quinine, on antropyloroduodenal motility, Plasma cholecystokinin, and enery intake in healthy men. J Neurogastroenterol Motil 25, 413-422.
Fierro F, Giogetti A, Carloni P, Meyerhof W, Alfonso-Prieto M (2019) Dual binding mode of "bitter sugars" to their human bitter taste receptor target. Sci Rep 9, 8437.
Nowak S, Di Pizio A, Levit A, Niv MY, Meyerhof W, Beherens M (2018) Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14. Biochim Biophys Acta Gen Subj 1862, 2162-2173.
Roosterman D, Meyerhof W, Cottrell GS (2018) Proton transport chains in glucose metabolism: Mind the Proton. Front Neurosci-Switz 12, 404.
Soares S, Silva MS, Garcia-Estevez I, Großmann P, Brás N, Brandao E, Mateus N, de Freitas V, Behrens M, Meyerhof W (2018) Human bitter taste receptors are activated by differnt classes of polyphenols. J Agric Food Chem 66, 8814-8823.
Di Pizio, A., Shy, N., Behrens, M., Meyerhof, W., Niv, M.Y. (2018) Molecular features underlying selectivity in chicken bitter taste receptors. Frontiers in Molecular Biosciences, section Structural Biology, eCollection 2018.
Behrens, M., Gu, M., Fan, S., Huang, C., Meyerhof, W., (2018) Bitter substances from plants used in traditional Chinese medicine exert biased activation of human bitter taste receptor. Chem. Biol. Drug Design 91, 422-433.
Lazutkaite, G., Solda, A., Lossow, K., Meyerhof, W., Dale, N. (2017) Amino acid sensing in hypothalamic tanycytes via umami taste receptors. Mol. Metab. 6, 1480-1492.
Prandi, S., Voigt, A., Meyerhof, W., Behrens, M. (2017) Expression profiling of Tas2r genes reveals a subset of Paneth cells expressing the Tas2r131 in mouse small intestine. Mol. Cell. Life Sci. 75, 49-65.
Lossow, K., Hermans-Borgmeyer, I., Behrens, M., Meyerhof, W. (2017) Genetic labeling of Car4 expressing cells reveals subpopulations of Type III taste cells. Chem. Senses 42, 747-758.
Behrens, M., Blank, K., Meyerhof, W. (2015) Blends of artificial sweeteners saccharin and cyclamate show reduced off-taste due to bitter taste receptor inhibition. Cell Chem. Biol. 24, 1199-1204.
Di Pizio, A., Kruetzfeldt, L-M., Cheled-Shoval, S., Meyerhof, W., Behrens, M., Niv, M. (2017) Predicting ligand binding modes using low resolution GPCR models: chicken bitter taste receptor ggTas2r1. Sci. Rep. 7, 8223.
Liszt, K.I., Ley, J.P., Lieder, B., Behrens, M., Reiner, A., Stöger, V., Hochkogler, C.M., Köck, E., Marchiori, A., Hans, J., Widder, S., Krammer, G., Meyerhof, W., Somoza, M.M., Somoza, V. (2017) Bitter taste receptors in the stomach regulate gastric acid secretion. Proc. Natl. Acad. Sci. 114, E6260-E6269.
Cheled-Shoval, S., Behrens, M., Korb, A., Di Pizio, A., Meyerhof, W., Uni, Z., Niv, M. (2017) From cell to beak: In vitro and in vivo characterization of chicken bitter taste threshold. Molecules 22, pii: E821.
Risso, D., Behrens, M., Sainz, E., Meyerhof, W., Drayna, D. (2017) Probing the evolutionary history of human bitter taste receptor pseudogenes by restoring their function. Mol. Biol. Evol. 34, 1587-1595.
Benford, H., Bolborea, M., Pollatzek, E., Lossow, K., Hermans-Borgmeyer, I., Meyerhof, W., Kasparoc, S., Dale, N. (2017) A sweet taste receptor-dependent mechanism of glucosensing in hypothalamic tanycytes. Glia, 65, 773-789.
Suess, B., Brockhoff, A., Meyerhof, W., Hofmann, T. (2016). The odorant R-citronellal attenuates caffeine bitterness by inhibiting the bitter receptors TAS2R43 and TAS2R46. J. Agric. Food Chem, Epub ahead of print.
Lossow, K., Hübner, S., Roudnitzky, N., Slack, J.P., Appendino, G., Behrens, M., Meyerhof W. (2016). Comprehensive analysis of mouse Tas2rs reveals different molecular receptive ranges for orthologous bitter taste receptors in mice and humans. J. Biol. Chem. 291, 15358-13377.
Roudnitzky, N., Risso, D., Drayna, D., Behrens, M., Meyerhof W., Wooding, S.P. (2016). Copy number variation in TAS2R bitter taste receptor genes: structure, origin, and population genetics. Chem. Senses 41, 649-659.
Karaman, R., Nowak, S. Di Pizio, A., Kitaneh, H., Abu-Jaish, A, Meyerhof, W., Niv, M.Y., Behrens, M. (2016). Probing the binding pocket of the broadly tuned human bitter taste receptor TAS2R14 by chemical modification of cognate agonists. Chem. Biol. Drug Design, 88, 66-75.
Larson, E.D., Vandenbeuch, A., Voigt, A., Meyerhof, W., Kinnamon, S.C. Finger, T.E. (2015). The role of 5-HT3 receptors in signaling from taste buds to nerves. J. Neurosci. 35, 15984-15995.
Backes, M., Obst, K., Bojahr, J., Thorhauer, A., Paetz, S., Reichelt, K.V., Krammer, G.E., Meyerhof, W., Ley, J.P. (2015) Rubemamine and rubescenamine, two naturally occurring N-Cinnamoyl phenethylamines are umami modulating compounds. J. Agr. Food Chem. 63, 627-639.
Roudnitzky, N., Behrens, M., Brockhoff, A., Hübner, S., Kohl, S., Lossow, K., Thalmann, S., Wooding, S.P., Meyerhof, W. (2015) Receptor polymorphisms and genomic structure interact to shape bitter taste perception. Plos Genetics, 11:e1005530.
Voigt, A., Hübner, S., Döring, L., Hermans-Borgmeyer, I., Boehm, U., Meyerhof, W. (2015) Cre-mediated recombination in Tas2r131 cells - a unique way to explore bitter taste receptor function inside and outside of the taste system. Chem. Senses 40, 627-639.
Sandal, M., Behrens, M., Brockhoff, A., Musiani, F., Giorgetti, A., Carloni, P., Meyerhof, W. (2015) Evidence for a transient additional ligand binding site in the TAS2R46 bitter taste receptor. J. Chem. Theory and Comput. 11, 4439-4449.
Voigt, A., Bojahr, J, Narukawa, M., Hübner, S., Boehm, U., Meyerhof, W. (2015). Transsynaptic tracing from taste receptor cells reveals local taste receptor gene expression in gustatory ganglia and brain. J. Neurosci. 35, 9717-9729.
Krasteva-Christ, G., Soultanova, A., Schütz, B., Papadakis, T., Weiss, C., Deckmann, K., Chubanov, V., Gudermann, T., Voigt, A., Meyerhof, W., Boehm, U., Weihe, E., and Kummer, W. (2015) Identification of cholinergic chemosensory cells in mouse tracheal and laryngeal glandular ducts. Int. Immunopharmacol. pii: S1567-5769(15)00257-X.
Soultanovaa, A., Voigt, A., Chubanovc, V., Gudermann, T., Meyerhof, W., Boehm, U., Kummer, W. (2015) Cholinergic chemosensory cells of the thymic medulla express the bitter receptor Tas2r131. Int. Immunopharmacol. pii: S1567-5769(15)00295-7.
Roura, E., Aldayyani, A., Thavaraj, P., Prakash, S., Greenway, D., Thomas, W.G., Meyerhof, W., Roudnitzky, N., Foster, S.R. (2015) Variability in human bitter taste sensitivity to chemically diverse compounds can be accounted for by differential TAS2R activation. Chem. Senses 40, 427-435.
Kusumakshi, S., Voigt, A., Hübner, S., Hermans-Borgmeyer, I., Ortali, A., Pyrski, M., Dörr, J., Zufall, F., Flockerzi, V., Meyerhof, W., Montmayeur, P., Boehm, U. (2015) A binary genetic approach to characterize TRPM5 cells in mice. Chem. Senses, 40, 413-425.
Clark, A.A, Dotson, C.D., Elson, A.E.T., Voigt, A., Boehm, U., Meyerhof, W., Steinle, N.I., and Munger, S.D (2015) TAS2R bitter receptors regulate human thyroid function. FASEB J. 29, 164-172.
Cheled-Shoval, S.L., Behrens, M., Meyerhof, W., Niv, M.Y., Zehava, U. (2014) Perinatal administration of a bitter tastant influences gene expression in Chicken palate and duodenum. J. Agr. Food Chem 62, 12512-12520.
Suess, B., Brockhoff, A., Degenhardt, A., Billmayer, S., Meyerhof, W., Hofmann, T. (2014) Human taste and umami receptor responses to chemosensorica generated by Maillard-type N2-alkyl-and N2-arylthiomethylation of guanosine 5’-monophosphates. J. Agr. Food Chem. 62, 11429-11440.
Behrens, M., Korsching, S., Meyerhof, W. (2014) Tuning properties of avian and frog bitter taste receptors dynamically fit gene repertoire sizes. Mol. Biol. Evol. 31, 3216-3227.
Foster, S.R., Blank, K., See Hoe, L.E., Behrens, M., Meyerhof, W., Peart, J.N., Thomas, W.G. (2014) Bitter taste receptor agonists elicit G-protein-dependent negative inotropy in the murine heart. FASEB J. 28, 4497-4508.
Behrens, M., Frank, O., Rawel, H., Potting, C., Hofmann, T., Meyerhof, W., Korsching, S. (2014) ORA1, a zebrafish olfactory receptor ancestral to all mammalian V1R genes, recognizes 4-hydroxyphenylacetic acid, a putative reproductive pheromone. J. Biol. Chem. 289, 19778-19788.
Voigt, N., Stein, J., Galindo, M.M., Dunkel, A., Abakuks, S., Raguse, J.-D. , Meyerhof, W., Hofmann, T., Behrens, M. (2014) The role of lipolysis in human orosensory fat perception. J. Lipid Res. 55, 870-882.
Levit, A, Nowack, S., Peters, M., Wiener, A., Meyerhof, W., Behrens, M., Niv, M.Y. (2014) The bitter pill: clinical drugs that activate bitter taste receptor TAS2R14. FASEB J 28, 1181-1197.
Prandi, S., Bromke, M., Hübner, S., Voigt, A., Boehm, U., Meyerhof, W., Behrens M. (2013) A subset of mouse colonic goblet cells express the bitter receptor Tas2r131. Plos one 8, e82820.
Suess, B., Brockhoff, A., Meyerhof, W., and Hofmann, T., (2013) Structures, orosensory activity, and T1R1/T1R3-receptor activation of amides generated by lactone aminolysis using food-related processing conditions. European Food Processing and Technology 237, 57-70.
Marchiori, A., Capece, L., Giorgetti, A., Gasparini, P., Behrens, M., Carloni, P., and Meyerhof W. (2013) Coarse-Grain/molecular mechanics of the TAS2R38 bitter taste receptor: experimentally validated detailed structural prediction of agonist binding. Plos one 8, e64675.
Foster, S.R., Porello, E.R., Purdue, B., Chan, H.-W., Voigt, A., Frenzel, S., Hannan, R.D., Moritz, K.M., Simmons, D.G., Roura, E., Boehm, U., Meyerhof, W., Thomas, W.G. (2013) Expression, regulation and putative nutrient sensing function of taste GPCRs in the heart. Plos one 8, e64579.
Thalmann, S., Behrens, M., and Meyerhof, W. (2013) Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol. Biophys. Biochem. Res. Commun. 435, 267-273.
Behrens, M., Gunn, H.C., Ramos, P.C.M., Meyerhof, W., and Wooding, S.P. (2013) Genetic, functional and phenotypic diversity in TAS2R38-mediated bitter taste perception, Chem. Senses 6, 475-484.
Kusuhara, Y., Yoshida, R., Ohkuri, T., Yasumatsu, K., Voigt, A., Hübner, S., Boehm, U., Meyerhof, W., Ninomiya, Y. (2013) Taste responses in mice lacking taste receptor T1R1. J. Physiol. 591, 1967-1985.
Soares, S., Thalmann, S., Kohl, S., Meyerhof W., Mateus, N., and Freitas, V. (2013) Different families of phenolic compounds activate distinct subsets of human TAS2R bitter taste receptors. J. Agr. Food Chem. 61, 1525-1533.
Kohl, S., Behrens, M., Dunkel, A., Hofmann, T., Meyerhof, W. (2013) Amino acids and peptides activate at least five members of the human bitter taste receptor family. J. Agr. Food Chem. 61, 53-60.
Born, S., Levit, A., Niv, M.Y., Meyerhof, W., Behrens, M. (2013) The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands. J. Neurosci. 33, 201-213.
Hillmann, H., Mattes, J., Brockhoff, A., Dunkel, A., Meyerhof, W., Hofmann, T. (2012) Senosomics analysis of taste compounds in balsamic vinegar and discovery of 5-acetoxymethyl-2-furaldehyde as a novel sweet taste modulator J. Agr. Food Chem. 60, 9974-9990.
Hellfritsch, C., Stähler, F., Brockhoff, A., Meyerhof, W., Hofmann, T. (2012) Human psychometric and taste receptor responses to steviol glycosides. J. Agr. Food Chem. 60, 6782-6793.
Voigt, A., Hübner, S., Loßow, K., Boehm, U., Meyerhof, W. (2012) Genetic labeling of Tas1r1 and Tas2r131 taste receptor cells in mice. Chem. Senses 37, 897-911.
Poirer, N., Roudnitzky, N., Brockhoff, A., Belloir, C., Maison, M., Danguin, T.T., Meyerhof, W., Briand, L. (2012) Efficient production and characterization of sweet-tasting brazzein secreted by the yeast Pichia pastoris. J. Agr. Food Chem. 60, 9807-98014.
Sigoillot, M., Brockhoff, A., Lescop, E., Poirer, N., Meyerhof, W., and Briand, L. (2012) Optimization of the production of gurmarin, a sweet-taste-suppressing protein, secreted by the methylotrophic yeast Pichia pastoris. Appl Microb Biotech 96, 1253-1263.
Behrens, M., Born, S., Redel, U., Schuh, V., Raguse, J.-D., Meyerhof, W. (2012) Immunohistochemical detection of hTAS2R38 protein in human taste cells. Plos one 7, e40304.
Meyer, D., Voigt, A., Widmayer, P., Borth, H., Huebner, S., Breit, A., Marschall, S., Hrabé de Angelis, M., Boehm, U., Meyerhof, W., Gudermann, T., and Boekhoff I. (2012) Expression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca2+ and cAMP concentrations in spermatozoa. Plos one 7, e32354.
Galindo, M.M., Voigt, N., Stein, J., van Lengerich, J., Raguse, J.-D., Hofmann, T., Meyerhof , W., and Behrens, M. (2012) G protein-coupled receptors in human fat taste perception. Chem. Senses 37, 123-139.
Schindler, A., Dunkel, A., Stähler, F., Backes, Ley, Meyerhof, and Hofmann, T. (2011) Discovery of salt taste enhancing arginyl-dipeptides in protein digests and fermented fish sauces by means of a sensomics approach. J. Agr. Food Chem. 59, 12578-12588.
Brockhoff, A., Behrens, M., Roudnitzky, N., Maison, M., Appendino, G., Avoto, C., and Meyerhof, W. (2011) Perceived bitterness of mixed compounds is based on receptor agonism and antagonism. J. Neurosci. 31, 14775-14782.
Nouzova, M., Brockhoff, A., Mayoral, J.G., Goodwin, M., Meyerhof, W., and Noriega, F.G. (2012) Functional characterization of an allatotropin receptor expressed in the corpora allata of mosquitoes. Peptides 34, 201-208.
Festring, D., Brockhoff, A., Meyerhof, W., and Hofmann, T. (2011) Stereoselective synthesis of amides sharing the guanosine 5'-monophosphate scaffold and umami enhancement studies using human Sensory and hTR1/rT1r3 receptor assays. J. Agr. Food Chem. 59, 8875-8885.
Roudnitzky, N., Bufe, B., Thalmann, S., Kuhn, C., Gunn, H.C., Meyerhof, W., and Wooding, S. (2011) Genomic, genetic, and functional dissection of bitter taste responses to artificial sweeteners. Hum. Mol. Gen. 20, 3437-3449.
Klose, C., Straub, I., Riehle, M., Ranta, F., Krautwurst, D., Ullrich, S., Meyerhof, W., and Harteneck, C. (2011) Fenamates as TRP channel blockers: mefanamic acid selectively blocks TRPM3. Br. J. Pharmacol. 162, 1757-1769.
Biarnés, X., Marchiori, A., Giorgetti, A., Lanzara, C., Gasparini, P., Carloni, P., Born, S., Brockhoff, A., Behrens, M., and Meyerhof, W. (2010). Insights into the binding of phenylthiocarbamide (PTC) agonist to its target human TAS2R38 bitter receptor. PLOS one 5, 12394.
Wooding, S.P., Gunn, H.C., Ramos, P.C.M., Thalmann, S., Xing, C., and Meyerhof, W. (2010) Genetics and bitter taste responses to goitrin, a plant toxin found in vegetables. Chem. Sens. 35, 685-692.
Slack, J.P., Brockhoff, A., Batram, C., Menzel, S., Sonnabend, C., Born, S., Galindo, M.M, Kohl, S., Thalmann, S., Ostopovici-Halip, L., Simons, C.T., Ungureanu, I., Duineveld, K., Bologa, C.G., Behrens, M., Furrer, S., Oprea, T.I., and Meyerhof, W (2010) Modulation of Bitter Taste Perception by a Small Molecule hTAS2R Antagonist. Curr. Biol. 20, 1104-1109.
Kuhn, C., Bufe, B., Batram, C., and Meyerhof, W. (2010) Oligomerization of TAS2R bitter taste receptors. Chem. Senses 35, 395-406.
Brockhoff, A., Behrens, M., Niv, M., and Meyerhof, W. (2010) Structural requirements of bitter taste receptor activation. Proc. Natl. Acad. Sci. USA 107, 11110-11115.
Meyerhof, W., Batram, C., Kuhn, C., Brockhoff, A., Chudoba, E., Bufe, B., Appendino, G. and Behrens, M. (2010) The molecular receptive ranges of human TAS2R bitter taste receptors. Chem. Senses 35, 157-170.
Behrens, M., Brockhoff, A., Batram, C., Kuhn, C., Appendino, G., and Meyerhof, W. (2009) The human bitter taste receptor hTAS2R50 is activated by the two natural bitter substances, andrographolide and amarogentin. J. Agr. Food Chem. 57, 9860-9866.
Intelmann, D., Batram, C., Kuhn, C., Haseleu, G., Meyerhof, W., and Hofmann, T. (2009) Three TAS2R bitter taste receptors mediate the psychophysical responses to bitter compounds of Hops (Humulus lupulus L.) and beer. Chemosensory Perception 2, 118-132.
Mayoral, J.G., Nouzova, M., Brockhoff, A., Goodwin, M., Hernandez-Martinez, S., Richter, D., Meyerhof, W., and Noriega, F.G. (2009) Allostatin-C receptors in mosquitoes. Peptides 31, 442-450.
Behrens, M., Buck, F., and Meyerhof, W. (2009) Substrate specificity of rat DESC4, a type II transmembrane serine protease. Prot. Pept. Lett. 16, 1-6.
Roosterman, D., Brune, N.E.I., Kreuzer, O.J., Feld, M., Pauser, S., Zarse, K., Steinhoff, M., and Meyerhof, W. (2008) Intracellular degradation of somatostatin-14 following sst3-mediated endocytosis in rat insulinoma cells. FEBS Journal 275, 4728-4739.
Hennigs, J.K., Burhenne, N., Stähler, F., Winnig, M, Walter, B., Meyerhof, W., and Schmale, H. (2008) Sweet taste receptor interacting protein CIB1 is a general inhibitor of InsP3 –dependent Ca2+–release in vivo. J. Neurochem. 106, 2249-2262.
Gray, J.C., Haptemariam, A., Winnig, M., Meyerhof W., and Sadler P. (2008) Sweetening ruthenium and osmium: organometallic arene complexes containing aspartame. J. Biol. Inorg. Chem. 13, 1111-1120.
Reichling, C., Behrens, M., and Meyerhof, W. (2008) Functions of human bitter taste receptors depend on N-glycosylation. J Neurochem. 106, 1138-1148.
Shirokova, E., Raguse, J.-D., Hopf, M., Meyerhof, W., and Krautwurst, D. (2008) The human vomeronasal type-1 receptor family – RNA expression, odorant detection and olfactory-specific signal transduction. FASEB J. 22, 1416-1425.
Stähler, F., Riedel, K., Demgensky, S., Neumann K., Dunkel, A., Täubert, A., Raab, B., Behrens, M., Raguse, J.-D., Hofmann, T., and Meyerhof, W. (2008) A role of the Epithelial Sodium Channel in Human Salt Taste Transduction? Chemosensory Perception 1, 78-90.
Carlo, A.-S., Pyrski, M., Loudes, C., Faivre-Baumann, A., Epelbaum, J., Williams, L., and Meyerhof, W. (2007) Leptin sensitivity in the developing rat brain. Endocrinology, 148, 6073-6082.
Behrens, M., Foerster, S., Staehler, F., Raguse, J.-D., and Meyerhof, W. (2007) Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells. J Neurosci. 27, 12630-12640.
Winnig, M., Bufe, B., Kratochwil, N.A., Slack, J.P, and Meyerhof, W. (2007) The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor. BMC Struct Biol., 7:66.
Schmiedeberg, K., Shirokova, E., Weber, H.-P., Reden, J., Schilling, B., Hummel, T., Meyerhof, W., and Krautwurst, D. (2007) Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1R2. J Struct Biol., 159, 400-412.
Brockhoff, A., Behrens, M., Massarotti A., Appendino, G. and Meyerhof, W. (2007) Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, diterpenes, strychnine and denatonium benzoate. J Agric Food Chem., 55, 6236-6242.
Carlo, A.-S., Meyerhof, W., and Williams, L. (2007) Early developmental expression of leptin receptor gene and [125I]Leptin binding in the rat brain. J Chem Neuroanat., 55, 155-163.
Schmolz, K., Pyrski, M., Bufe, B., Vogel, H., Nogueiras, R., Scherneck, S., Nestler, M., Zahn, C., Rüschendorf, F., Tschöp, M., Meyerhof, W., Joost, H.-G., and Schürmann, A. (2007) Role of neuromedin-U in the central control of feeding behavior: A variant of the neuromedin-U receptor 2 contributes to hyperphagia in the New-Zealand Obese mouse. Obesity and Metabolism, 3, 28-37.
Roosterman, D., Kreuzer, O., Brune, N., Bunnett, N.W., Meyerhof, W., and Steinhoff, M. (2007) Lipids rafts mediate trafficking and endocytosis of somatostatin receptor 1. Endocrinology, 148, 1050-1058.
Stepanyan, Z., Kocharyan, A., Behrens, M., Pyrski, M., and Meyerhof W. (2007) Somatostatin, a negative-regulator of central leptin action in the rat hypothalamus. J. Neurochem., 100, 468-478.
Galindo-Cuspinera, V., Winnig, M., Bufe, B., Meyerhof, W., and Breslin, P.A.S. (2006) A TAS1R receptor-based explanation of sweet water taste. Nature, 441, 354-357.
Wooding, S., Bufe, B., Grassi, C., Howard, M.T., Stone, A.C., Vazquez, M., Dunn, D.M., Meyerhof, W., Weiss, R.B., and Bamshad, M.J. (2006) Convergent evolution of bitter taste sensitivity in humans and chimpanzees. Nature, 440, 930-934.
Behrens, M., Bartelt, J., Reichling, C., Winnig, M., Kuhn, C. and Meyerhof, W. (2006) Members of RTP and REEP gene families influence functional bitter taste receptor gene expression. J Biol Chem., 281, 20650-9.
Hinrichs, A.L., Wang, J.C., Bufe, B., Kwon, J.M., Budde, J., Allen, R., Bertelsen, S., Evans, W., Dick, D., Rice, J., Foroud, T., Nurnberger, J., Tischfield, J.A., Kuperman, S., Crowe, R., Hesselbrock, V., Schuckit, M., Almasy, L., Porjesz, B., Edenberg, H.J., Begleiter, H., Meyerhof, W., Bierut, L.J., and Goate, A.M. (2006) Missense Mutation in a Bitter Taste Receptor (hTAS2R16) Influences Risk for Alcohol Dependence. Am. J Hum Genetics, 78, 103-11.
Lang, M., Bufe, B., De Pol, S., Reiser, O., Meyerhof, W. and Beck-Sickinger, A.G. (2006) Structural properties of orexins for activation of their receptors. J Pept Sci., 12, 258-266.
Soranzo, N., Bufe, B., Sabeti, P., Wilson, J.F., Weale, M.E., Marguerie, R., Meyerhof, W., and Goldstein, D.B. (2005) Positive selection on a functional allele of the human TAS2R16 bitter taste receptor associated with higher sensitivity to b-glucopyranosides. Curr Biol., 15, 1257-1265.
Winnig, M., Bufe, B. and Meyerhof, W. (2005) Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate intensitivity towards lactisole of the rat sweet taste receptor. BMC Neuroscience, 22.
Bufe, B., Breslin, P.S.A., Kuhn, C., Reed, D.R., Tharp, C.D., Slack, J.P., Kim, U.-K., Drayna, D. and Meyerhof W. (2005) The Molecular Basis of Individual Differences in Phenylthiocarbamide and Propylthiouracil Bitterness Perception. Curr Biol., 15, 322-327.
Behrens, M., Brockhoff, A., Kuhn, C., Bufe, B., Winnig, M. and Meyerhof, W. (2004) The human taste receptor hTAS2R14 responds to a variety of different bitter compounds. Biochem Biophys Res Commun., 319, 479-485.
Behrens, M., Bufe, B., Schmale, H. and Meyerhof, W. (2004) Molecular cloning and characterisation of DESC4, a new transmembrane serine protease. Cell Mol Life Sci., 61, 2866-2877.
Shirokova, E., Schmiedeberg, K., Bedner, P., Niessen H., Willecke, K., Raguse, J.-D., Meyerhof W. and Krautwurst, D. (2005) Identification of specific ligands for orphan olfactory receptors. G protein-dependent agonism and antagonism of odorants. J Biol Chem., 280, 11807-11815.
Kuhn, C., Bufe, B., Winnig, M., Hofmann, T., Frank, O., Behrens, M., Lewtschenko, T., Slack, J.P., Ward, C.D. and Meyerhof W. (2004) Bitter receptors for saccharin and acesulfame K. J Neurosci., 24 10260-10265.
Stepanyan, Z., Kocharyan, A., Pyrski, M., Hübschle, T., Watson, A.M.D., Schulz, S. and Meyerhof, W. (2003) Leptin-Target Neurons of Rat Hypothalamus Express Somatostatin Receptors. J Neuroendocrinology, 15, 822-830.
Bufe, B., Hofmann, T., Krautwurst, D., Raguse, J.-D. and Meyerhof W. (2002) The human TAS2R16 receptor mediates bitter taste in response to b-glucopyranosides. Nature Genetics, 32, 397-401.
Ammon, C., Schäfer, J., Kreuzer, O.J. and Meyerhof, W. (2002) Presence of a plasma membrane targeting sequence in the amino-terminal region of the rat somatostatin receptor 3. Arch Physiol Biochem., 110, 137-145.
Baumeister, H., Schärfke, M., Haebel, S. and Meyerhof, W. (2001) A two-dimensional map and a database of soluble nuclear proteins from HepG2 cells. Eur J Nutr., 40, 168-177.
Florian, S., Wingler, K., Schmehl, K., Jacobasch, G., Kreuzer, O.J., Meyerhof, W. and Brigelius-Flohé, R. (2001) Cellular and subcellular localization of gastrointestinal gluthathione peroxidase in normal and malignant human intestinal tissue. Free Radical Res., 35, 655-663.
Stevens, D.R., Seifert, R. Bufe, B., Müller, F., Kremmer, E., Gauss, R., Meyerhof, W., Kaupp, U.B. and Lindemann, B. (2001) The hyperpolarization-activated channels HCN1 and 4 mediate responses to sour stimuli. Nature 413, 631-635.
Hübschle, T., Harré, E.-M., Meyerhof, W., Pehl, U., Roth, J. and Gerstberger, R. (2001) The central pyrogenic action of interleukin-6 is related to nuclear translocation of STAT3 in the anteroventral preoptic area of the rat brain. J Therm Biol., 26, 299-305.
Hübschle, T., Thom, E., Watson, A.M.D., Roth, J., Klaus, S. and Meyerhof, W. (2001) Leptin-induced nuclear translocation of STAT3-immunoreactivity in hypothalamic nuclei involved in body weight regulation. J Neuroscience, 21, 2413-2424.
Schärfke, M., Baumeister, H., and Meyerhof, W. (2001) A method for the immunological detection of silver stained proteins on nitrocellulose membranes. Biotechniques, 30, 266-272.
Kreuzer, O.J., Krisch, B., Déry, O., Bunnett, N.W. and Meyerhof, W. (2001) Agonist-mediated endocytosis of rat somatostatin receptor subtype 3 involves b-arrestin and clathrin coated vesicles. J Neuroendocrinology, 13, 279-287.
Nehring, R.B., Richter, D. and Meyerhof, W. (2000) Glycosylation affects agonist binding and signal transduction of the rat somatostatin receptor subtype 3. J Physiol., (Paris) 94, 185-192.
Baumeister, H. and Meyerhof, W. (2000) The POU domain transcription factor Tst-1 activates somatostatin receptor 1 gene expression in pancreatic b-cells. J Biol Chem., 275, 28882-28887.
Bufe, B., Schmale, H. and Meyerhof, W. (2000) Induction of membrane chloride currents in Xenopus laevis oocytes by the sulfonyl amide sweeteners acesulfame K and saccharin. J Recept Sig Trans Res., 20, 153-166.
Baumeister, H., Wegner, M., Richter, D. and Meyerhof, W. (2000) Dual regulation of somatostatin receptor subtype 1 gene expression by Pit-1 in anterior pituitary GH3 cells. Mol Endocrinol., 14, 255-271.
Kreienkamp, H.-J., Akgün, E., Baumeister, H., Meyerhof, W. and Richter, D. (1999) Somatostatin receptor subtype 1 modulates basal inhibition of growth hormone release in somatotrophs. FEBS Lett., 462, 464-466.
Schäfer, J. and Meyerhof, W. (1999) sst1 mRNA is the prominent somatostatin receptor mRNA in the rat gastrointestinal tract: reverse transcription polymerase chain reaction and in situ-hybridization study. Neuropeptides, 33, 457-463.
Glassmeier, G., Höpfner, M., Riecken, E-.O., Mann, B., Buhr, H., Neuhaus, P., Meyerhof, W. and Scherübl, H. (1998) Inhibition of L-type calcium channels by octreotide in isolated human neuroendocrine tumor cells of the gut. Biochem Biophys Res Commun., 250, 511-515.
Tensen, C.P., Cox, K.J.A., Smit, A.B., van der Schors, R.C., Meyerhof, W., Richter, D., Planta, R.J., Hermann, P.M., van Minnen, J., Geraerts, W.P.M., Knol, J.C., Burke, J.F., Vreugdenhil, E. and van Heerikhuizen, H. (1998) The Lymnaea cardioexcitatory peptide (LyCEP) receptor: a G protein-coupled receptor for a novel member of the RFamide neuropeptide family. J Neuroscience, 18, 9812-9821.
Roosterman, D., Glassmeier, G., Baumeister, H., Scherübl, H. and Meyerhof, W. (1998) A somatostatin receptor 1 selective ligand inhibits Ca2+-currents in rat insulinoma 1046-38 cells. FEBS Lett., 425, 137-140.
Baumeister, H., Kreuzer, O., Roosterman, D., Schäfer, J., and Meyerhof, W. (1998) Cloning, expression, pharmacology and tissue distribution of the mouse somatostatin receptor subtype 5. J Neuroendocrinology, 10, 283-290.
Lamszus, K., Meyerhof, W. and Westphal, M. (1997) Somatostatin and somatostatin receptors in the diagnosis and treatment of gliomas. J Neuro-Oncol., 35, 353-364.
Roth, A., Kreienkamp, H.-J., Meyerhof, W. and Richter, D. (1997) Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization. J Biol Chem., 272, 23769-23774.
Viollet, C., Bodenant, C., Prunotto, C., Roosterman, D., Schaefer, J., Meyerhof, W., Epelbaum, J. Vaudry, H. and Leroux, P. (1997) Differential expression of multiple somatostatin receptors in the rat cerebellum during development. J Neurochem., 66, 2263-2272.
Borson-Chazot, F., Houzard, C., Ajzenberg, C., Nocaudie, M., Duet, M., Mundler, O., Marchandise, X., Epelbaum, J., Gomez de Alzaga, M., Schaefer, J., Meyerhof, W., Sassolas, G. and Warnet, A. (1997) Somatostatin receptor imaging in somatotroph and non functioning pituitary adenomas: correlation with hormonal and visual responses to octreotide. Clinic Endocr., 47, 589-598.
Roosterman, D., Roth, A., Kreienkamp, H.-J., Richter, D. and Meyerhof, W. (1997) Distinct agonist-mediated endocytosis of cloned rat somatostatin receptor subtypes expressed in insulinoma cells. J Neuroendocrinol., 9, 741-751.
Roth, A., Kreienkamp, H.-J., Nehring, R.B., Roosterman, D., Meyerhof, W. and Richter, D. (1997) Endocytosis of the rat somatostatin receptors: subtype discrimination, ligand specificity, and delination of carboxy terminal positive and negative sequence motifs. DNA and Cell Biol., 16, 111-118.
Hausmann, H., Richters, A., Kreienkamp, H.-J., Meyerhof, W., Mattes, H., Lederis, K., Zwiers, H. and Richter, D. (1996) Mutational analyses and molecular modelling of the nonapeptide hormone binding domains of the [Arg8]vasotocin receptor. Proc Natl Acad Sci., USA 93, 6907-6912.
van Kesteren, R.E., Tensen, C.P., Smit, A.B., van Minnen, J., Kolakowski, Jr., L. F., Meyerhof, W., Richter, D., van Heerikhuizen, H., Vreugdenhil, E. and Geraerts, W.P.M. (1996) Co-evolution of ligand-receptor pairs in the vasopressin/oxytocin superfamily of bioactive peptides. J Biol Chem., 271, 3619-3626.
John, M., Meyerhof, W., Richter, D., Waser, B., Schaer, J.-C., Scherübl, H., Boese-Landgraf, J., Neuhaus, P., Ziske, C., Mölling, K., Riecken, E.-O., Reubi, J.C. and Wiedenmann, B. (1996) Positive somatostatin receptor scintigraphy correlates with the presence of somatostatin receptor subtype 2. Gut, 38, 33-39.
Nehring, R. B., Meyerhof, W. and Richter, D. (1995) Aspartic acid residue 124 in the third transmembrane domain of the somatostatin receptor subtype 3 is essential in binding somatostatin 14. DNA and Cell Biol., 14, 939-944.
Hausmann, H., Meyerhof, W., Zwiers, H., Lederis, K. and Richter, D. (1995) Teleost isotocin receptor: structure, functional expression, mRNA distribution and phylogeny. FEBS Letters, 370, 227-230.
Falk, T., Meyerhof, W., Corrette, B.J., Schäfer, J., Bauer, C.K., Schwarz, J.R. and Richter, D. (1995) Cloning, functional expression and mRNA distribution of an inwardly rectifying potassium channel protein. FEBS Letters, 367, 127-131.
van Kesteren, R.E., Tensen, C.P., Smit, A.B., van Minnen, J., van Soest, P. F., Kits, K.S., Meyerhof, W., Richter, D., van Heerikhuizen, H., Vreugdenhil, E. and Geraerts, W.P.M. (1995) A novel member of the vasopressin/oxytocin receptor family: cloning, expression and functions of a Lymnea conopressin receptor. Neuron, 15, 897-908.
Epelbaum, J., Bertherat, J., Prevost, G., Kordon, C., Meyerhof, W., Wulfsen, I., Richter, D. and Plouin, P.-F. (1995) Molecular and pharmacological characterization of somatostatin receptor subtypes in adrenal, extradrenal and malignant phaeochromocytomas. J Clinic Endocr Metab., 80, 1837-44.
Hartmann, D., Fehr, S., Meyerhof, W. and Richter, D. (1995) Distribution of somatostatin receptor subtype 1 mRNA in the developing cerebral hemispheres of the rat. Dev Neuroscience, 17, 246-255.
Vanetti, M., Schönrock, C., Meyerhof, W. and Höllt, V. (1994) Molecular cloning of a bovine MSH receptor which is highly expressed in the testis. FEBS Letters, 348, 268-272.
Hauser, F., Meyerhof, W., Wulfsen, I., Schönrock, C. and Richter, D. (1994) Sequence Analysis of the Promoter Region of the Rat Somatostatin Receptor Subtype 1 Gene. FEBS Letters, 345, 225-228.
Mahlmann, S., Meyerhof, W., Hausmann, H., Heierhorst, J. Schönrock, C., Zwiers, H., Lederis, K. and Richter, D. (1994) Structure and phylogeny of teleost vasotocin receptors. Proc Natl Acad Sci., USA 91, 1342-1345.
Wulfsen, I., Meyerhof, W., Fehr, S. and Richter, D. (1993) Expression patterns of rat somatostatin receptor genes in pre and postnatal brain and pituitary. J Neurochem., 61, 1549-1552.
Meyerhof, W., Obermüller, F., Fehr, S. and Richter, D. (1993) A novel rat serotonin receptor: primary structure, pharmacology and expression pattern in distinct brain regions. DNA Cell Biol., 12, 401-409.
Meyerhof, W., Wulfsen, I., Schönrock, C., Fehr, S. and Richter, D. (1992) Molecular cloning of a somatostatin-28 receptor and comparison of its expression pattern with that of a somatostatin-14 receptor in rat brain. Proc Natl Acad Sci., USA 89, 10267-10271.
Meyerhof, W., Schwarz, J.R., Bauer, C.K., Hübel, A. and Richter, D. (1992) A rat pituitary tumour K+ Channel expressed in frog oocytes induces a transient K+ current indistinguishable from that recorded in native cells. J Neuroendocrinol., 4, 245-253.
Meyerhof, W., Paust, H.-J., Schönrock, C. and Richter, D. (1991) Cloning of a novel putative G protein-coupled receptor expressed in specific rat brain regions. DNA Cell Biol., 10, 689-694.
Guse, A.H., Gercken, G., Boysen, H., Schwarz, J.R. and Meyerhof, W. (1991) Inositol tetrakisphosphates as second messengers induce Ca++ dependent chloride currents in Xenopus laevis oocytes. Biochem Biophys Res Commun., 179, 641-647.
Buck, F., Meyerhof, W., Werr, H. and Richter, D. (1991) Characterization of N- and C- terminal deletion mutants of the rat serotonin HT2 receptor in Xenopus oocytes. Biochem Biophys Res Commun., 178, 1421-1428.
Meyerhof, W., Müller-Brechlin, R. and Richter, D. (1991) Molecular cloning of a novel putative G-protein coupled receptor expressed during rat spermiogenesis. FEBS Letters, 284, 155-160.
Meyerhof, W., and Richter, D. (1990) Identification of G protein-coupled receptors by RNase H-mediated hybrid depletion using Xenopus laevis oocytes as expression system. FEBS Letters, 266,192-194.
Bauer, C.K, Meyerhof, W. and Schwarz, J.R. (1990) An inward-rectifying K+ current in GH3 rat anterior pituitary cells and its modulation by thyrotropin-releasing hormon. J Physiol., 429, 169-189.
Wright, M.S., Karlsen, H.E., Paulssen, E.J., Meyerhof, W., Hogset, A. and Gautvik, K.M. (1990) Different size mRNAs from GH4C1 cells induce a TRH-dependent electrical response in Xenopus laevis oocytes. Acta Physiologica Scandinavia, 140, 129-134.
Meyerhof, W., Schwarz, J.R., Höllt, V. and Richter, D. (1990) Expression of histamine H1-receptors in oocytes injected with mRNA from bovine adrenal medulla: Pertussis toxin insensitive activation of membrane chloride currents. J Neuroendocrinol., 2, 547-553.
Meyerhof, W., Stalder, J., Köster, M., Wirthmüller, U. and Knöchel, W. (1990) Sequence analysis of the upstream regions of Xenopus laevis ß-globin genes and arrangement of repetitive elements within the globin gene clusters. Mol Biol Rep., 14, 17-26.
Mahlmann, S., Meyerhof, W. and Schwarz, J.R. (1989) Different roles of IP4 and IP3 in the signal pathway coupled to the TRH receptor in microinjected Xenopus oocytes. FEBS Letters, 249, 108-112.
Mahlmann, S., Schwarz, J.R. and Meyerhof, W. (1989) Modulation of neuropeptide induced membrane currents by protein kinase C in Xenopus oocytes injected with GH3 pituitary cell poly(A)+RNA. J Neuroendocrinol., 1, 65-69.
Nietfeld, W., Digweed, M., Mentzel, H., Meyerhof, W., Köster, M., Knöchel, W., Erdmann, V. and Pieler, T. (1988) Oocyte and somatic 5S ribosomal RNA and 5S RNA encoding genes in Xenopus tropicalis. Nucleic Acids Res., 16, 8803-8815.
Meyerhof. W., Morley, S.D. and Richter, D. (1988) Expression and electrophysiological identification of the receptor for bombesin and gastrin releasing peptide in Xenopus laevis oocytes injected with polyA+ RNA from rat brain. FEBS Letters, 239, 109-112.
Knöchel, W., Pfanne, K., Beck, J. and Meyerhof, W. (1988) Nucleotide sequence of a larval a-globin gene from Xenopus tropicalis. Nucleic Acids Res., 16, 1625.
Stalder, J., Wirthmüller, U., Beck, J., Gruber, A., Meyerhof, W., Knöchel, W.and Weber, R. (1988) Primary structure and evolutionary relationshipbetween the adult a-globin genes and their 5’-flanking regions of Xenopus laevis and Xenopus tropicalis. J Mol Evol. 28, 64-71.
Morley, S.D., Meyerhof, W., Schwarz, J. and Richter, D. (1988) Functional expression of the oxytocin receptor in Xenopus oocytes primed with mRNA from bovine endometrium. J Mol Endocr., 1, 77-81.
Meyerhof, W., Morley, S.D., Schwarz, J. and Richter, D. (1988) Receptors for neuropeptides are induced by exogenous polyA+ RNA in oocytes from Xenopus laevis. Proc Natl Acad Sci., USA 85, 714-717.
Knöchel, W., Beck, J., and Meyerhof, W. (1987) Nucleotide sequence of the Xenopus tropicalis larval ß-globin gene. Nucleic Acids Res., 15, 10062.
Meyerhof, W., Wittig, B., Tappeser, B. and Knöchel, W. (1987) Transcription termination and processing of transcripts from tRNA related Xenopus satellite DNA sequences. Eur J Biochem., 164, 287-293.
Meyerhof, W., Korge, E. and Knöchel, W. (1987) Characterization of repetitive DNA transcripts isolated from a Xenopus laevis gastrula stage cDNA clone bank. Roux’s Arch Dev Biol., 196, 22-29.
Meyerhof, W., Köster, M., Stalder, J., Weber, R. and Knöchel, W. (1986) Sequence analysis of the larval ßII-globin gene of Xenopus laevis. Mol Biol Rep., 11, 155-161.
Knöchel, W., Korge, E. Basner, A. and Meyerhof, W. (1986) Globin evolution in the genus Xenopus: Comparative analysis of cDNAs coding for adult globin polypeptides of Xenopus borealis and Xenopus tropicalis. J Mol Evol., 23, 211-223.
Stalder, J., Meyerhof, W., Wirthmueller, U. Gruber, A., Wyler, T., Knöchel, W. and Weber, R. (1986) Conserved sequences and cell specific DNase I hypersensitive sites upstream the coordinately expressed aI- and aII globin genes of Xenopus laevis. J Mol Biol., 188, 119-128.
Knöchel, W., Meyerhof, W., Stalder, J. and Weber, R. (1985) Comparative nucleotide sequence analysis of two types of larval ß-globin mRNAs of Xenopus laevis. Nucleic Acids Res.13, 7899-7908.
Meyerhof, W., Klinger-Mitropoulos, S., Stalder, J. Weber, R. and Knöchel, W. (1984) The primary structure of the larval ßI- globin gene of Xenopus laevis and its flanking regions. Nucleic Acids Res., 12, 7705-7719.
Hummel, S., Meyerhof, W., Korge, E. and Knöchel, W. (1984) Characterization of highly and moderately repetitive 500 bp Eco RI fragments from Xenopus laevis DNA. Nucleic Acids Res. 12, 4921-4938.
Meyerhof, W., Tappeser, B., Korge, E. and Knöchel, W. (1983) Analysis of satallite DNA from Xenopus laevis: Comparative Analysis of 745 and 1037 base pair Hind III fragments. Nucleic Acid Res., 11, 6997-7009.
Knöchel,W., Meyerhof, W., Hummel, S., and Grundmann, U. (1983) Molecular cloning and sequencing of mRNAs coding for minor adult globin polypeptides of Xenopus laevis. Nucleic Acids Res., 11, 1543-1554.
Meyerhof, W., John, M.E., Thomaschek, G. and Knöchel, W. (1982) Repetitive sequences associated with polyadenylated RNA of Xenopus laevis embryos. Roux’s Arch Dev Biol., 191, 366-370.